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Research Articles
Antiestrogenic Activity of Anthropogenic and Natural Chemicals
Helmut Segner; José María Navas
Corresponding author:: Helmut Segner, Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstr. 15, D-04318 Leipzig, Germany
A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive gene s. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes. | | Keywords: Ah receptor, endocrine disrupters; antiestrogenicity, toxicological consequences; endocrine disrupters; estrogen receptors, endocrine disrupters |
5 ESPR (2) 75-82 (1998)
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