| Academic degree: | PhD |  | | Last name: | Gracia | | First name: | Tannia | | Responsible for: | | | Organization/Institute: | Wellcome Trust Sanger Insitute | | Department: | Fission Yeast Functional Genomics | | Position: | Postdoctoral Fellow | | Street, Number, POB: | Wellcome Trust Genome Campus | | Postal code, City: | CB10 1SA Hinxton | | State: | Cambridge | | Country: | UNITED KINGDOM | | Phone: | +44(0)1223-834244 Ext.868 | | Fax: | +44(0)1223-496802 | | E-mail address: | tg3@sanger.ac.uk | | Url: | | | Curriculum vitae: | TANNIA GRACIA Tel: +44-1223-834244, Ext.8686
Wellcome Trust Sanger Institute Fax: +44(0)1223-496802
Hinxton-Cambridge W: http://www.sanger.ac.uk/PostGenomics/S_pombe/
CB10 1HH, United Kingdom e-mail: tg3@sanger.ac.uk
PROFESSIONAL PROFILE
Disciplined, confident and goal oriented scientist with BS in Pharmaceutical Chemistry and PhD in Environmental Toxicology with training and experience in development and execution of research projects in academy and in the industry. Highly inquisitive, creative and resourceful, excited by the challenge of research and experimentation. Excellent skills in communication and collaboration. Efficient and organized leader dedicated to maintaining high quality standards.
Core competencies
Research and Development Experimental Design Activities Instrumental Analysis
Molecular Biology & Biochemical Analysis Quality Assurance Computational Chemistry
Field Work Industrial Safety Laboratory Management
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EDUCATION
PhD in Environmental Toxicology – MICHIGAN STATE UNIVERSITY
B S in Pharmaceutical Chemistry – UNIVERSIDAD DE CARTAGENA
PROFESSIONAL EXPERIENCE
Wellcome Trust Sanger Institute – Cambridge, UK 2006-Present
POST-DOCTORAL RESEARCH FELLOW
Implementation of the proteomic studies in the fission yeast functional genomic group.
? Protein purification protocols
? Mass Spectrometry sample preparation
? Mass spectrometry data analysis
Michigan State University – East Lansing, MI 2001-2006
GRADUATE RESEARCH ASSISTANT
Execution of the project “Optimization of the H295R Cell Line for Use in Evaluating Toxicant-Induced Effects of Steroidogenesis” funded by the U.S. Environmental Protection Agency. Key Accomplishments:
ExxonMobil de Colombia S.A. –Cartagena, Colombia 1997-2001
QUALITY ASSURANCE ANALYST
In charge of establishment of new ASTM, AMS and IP methods for the analysis of Fuels and Lubricating oils. Supervision of all instrumental methods of analysis including Atomic Absorption, Atomic Emission, Infrared and Inductively Coupled Plasma. Generation and supervision of quality assurance documentation. Evaluate test data and conformance to specified parameters as part of quality assurance objectives. Application and supervision of Good Laboratory Practices in order to sustain or surpass local and international standards.
Hydrographic and Oceanographic Research Center. Navy Army – Cartagena, Colombia. 1996-1997
CHEMICAL ANALYST
Chemical Characterization of water, sediments and plant material for the project: Strongly Contaminated Bays in Colombia. Key Accomplishments:
PUBLICATIONS
? Gracia, T., Jones, P.D., Higley, E., Newsted, J.L., Zhang, X., and Giesy, J.P. An in vitro study on endocrine disrupting activities in coastal water and sewage effluents of Hong Kong, China. Environ.Sci.Pollut.Res.Int. (Accepted for publication).
? Gracia, T., Jones, P.D., Hilscherova, K., Higley, E., Newsted, J.L., Zhang, X., and Giesy, J.P. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds Toxicol.Appl.Pharm 225, 142-153 (2007).
? Gracia, T., Hilscherova, K., Jones, P.D., Newsted, J.L., Zhang, X., Sanderson, T.S., Yu, R. and Giesy, J.P. The H295R system for evaluation of endocrine-disrupting effects. 65, 293-305 (2006).
? Ludek Blaha, Klara Hilscherova, Edita Mazurova,Markus Hecker, Paul D. Jones, Patrick Bradley, Tannia Gracia, Zdenek Duris, Ivan Holoubek, John P. Giesy. Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects. Environ.Intl. 32, 749-757 (2006).
? Zhang, X., Yu, R., Jones, P.D., Newsted, J.L., Gracia, T., Hecker, M., Hilscherova, K., Sanderson, T.S., Wu,R., and Giesy, J.P. Quantitative RT-PCR Methods for Evaluating Toxicant-Induced Effects on Steroidogenesis Using the H295R cell line. Environ.Sci.Tech. 39:2777-2785 (2005).
? Hilscherova, K., Jones, P.D., Gracia, T., Newsted, J.L., Zhang, X., Sanderson, T.S., Yu, R. and Giesy, J.P. Assessment of the Effects of Chemicals on Expression of Ten Steroidogenic Genes in the H295R Cell Line using Real Time PCR. Tox. Sci. 81, 78-89 (2004).
? Olivero, J., Gracia, T., Payares, P., Vivas, R., Diaz, D., Daza, E., and Geerlings, P. Molecular Structure and Gas Chromatographic Retention Behavior of Components of Ylang-Ylang Oil. J.Pharm.Sci. 86, 5(1997)
International Research Programs
City University of Hong Kong. Hong Kong. People’s Republic of China.
Research Center for Environmental Chemistry and Ecotoxicology, Masaryk University. Brno, Czech Republic.
University of Santiago de Compostela. Santiago de Compostela, Spain.
Awards
International Scholarship COLCIENCIAS. Auburn University. USA
Scholarship INTERCAMPUS AL. University of Santiago de Compostela. Spain
| | Areas of interest: | | antibiotics | | aquatic toxicology | | water and wastewater analysis | | molecular toxicology | | Ecotoxicolgical methods | | pharmaceutical compounds | | endocrine effects of chemicals | | |
| | Articles: | 15 ESPR (4) 332-343 (2008), Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay [full paper at: http://www.springerlink.com/content/112851/]
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